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- Title
NetworKIN: a resource for exploring cellular phosphorylation networks.
- Authors
Linding, Rune; Jensen, Lars Juhl; Pasculescu, Adrian; Olhovsky, Marina; Colwill, Karen; Bork, Peer; Yaffe, Michael B; Pawson, Tony
- Abstract
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase-substrate relations. Based on the latest human phosphoproteome from the Phospho.ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase-substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20,224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families.
- Publication
Nucleic acids research, 2008, Vol 36, Issue Database issue, pD695
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkm902