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- Title
OrthoDB: the hierarchical catalog of eukaryotic orthologs.
- Authors
Kriventseva, Evgenia V; Rahman, Nazim; Espinosa, Octavio; Zdobnov, Evgeny M
- Abstract
The concept of orthology is widely used to relate genes across different species using comparative genomics, and it provides the basis for inferring gene function. Here we present the web accessible OrthoDB database that catalogs groups of orthologous genes in a hierarchical manner, at each radiation of the species phylogeny, from more general groups to more fine-grained delineations between closely related species. We used a COG-like and Inparanoid-like ortholog delineation procedure on the basis of all-against-all Smith-Waterman sequence comparisons to analyze 58 eukaryotic genomes, focusing on vertebrates, insects and fungi to facilitate further comparative studies. The database is freely available at http://cegg.unige.ch/orthodb.
- Publication
Nucleic acids research, 2008, Vol 36, Issue Database issue, pD271
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkm845