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- Title
Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments.
- Authors
Gauthier, Nicholas Paul; Larsen, Malene Erup; Wernersson, Rasmus; de Lichtenberg, Ulrik; Jensen, Lars Juhl; Brunak, Søren; Jensen, Thomas Skøt
- Abstract
The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.
- Publication
Nucleic acids research, 2008, Vol 36, Issue Database issue, pD854
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkm729