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- Title
MADAP, a flexible clustering tool for the interpretation of one-dimensional genome annotation data.
- Authors
Schmid, Christoph D; Sengstag, Thierry; Bucher, Philipp; Delorenzi, Mauro
- Abstract
A recurring task in the analysis of mass genome annotation data from high-throughput technologies is the identification of peaks or clusters in a noisy signal profile. Examples of such applications are the definition of promoters on the basis of transcription start site profiles, the mapping of transcription factor binding sites based on ChIP-chip data and the identification of quantitative trait loci (QTL) from whole genome SNP profiles. Input to such an analysis is a set of genome coordinates associated with counts or intensities. The output consists of a discrete number of peaks with respective volumes, extensions and center positions. We have developed for this purpose a flexible one-dimensional clustering tool, called MADAP, which we make available as a web server and as standalone program. A set of parameters enables the user to customize the procedure to a specific problem. The web server, which returns results in textual and graphical form, is useful for small to medium-scale applications, as well as for evaluation and parameter tuning in view of large-scale applications, requiring a local installation. The program written in C++ can be freely downloaded from ftp://ftp.epd.unil.ch/pub/software/unix/madap. The MADAP web server can be accessed at http://www.isrec.isb-sib.ch/madap/.
- Publication
Nucleic acids research, 2007, Vol 35, Issue Web Server issue, pW201
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkm343