We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
GeneTrail--advanced gene set enrichment analysis.
- Authors
Backes, Christina; Keller, Andreas; Kuentzer, Jan; Kneissl, Benny; Comtesse, Nicole; Elnakady, Yasser A; Müller, Rolf; Meese, Eckart; Lenhof, Hans-Peter
- Abstract
We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representation Analysis' (ORA) comparing a reference set of genes to a test set, and 'Gene Set Enrichment Analysis' (GSEA) scoring sorted lists of genes. Besides other newly developed features, GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably. GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de.
- Publication
Nucleic acids research, 2007, Vol 35, Issue Web Server issue, pW186
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkm323