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- Title
RNAhybrid: microRNA target prediction easy, fast and flexible.
- Authors
Krüger, Jan; Rehmsmeier, Marc
- Abstract
In the elucidation of the microRNA regulatory network, knowledge of potential targets is of highest importance. Among existing target prediction methods, RNAhybrid [M. Rehmsmeier, P. Steffen, M. Höchsmann and R. Giegerich (2004) RNA, 10, 1507-1517] is unique in offering a flexible online prediction. Recently, some useful features have been added, among these the possibility to disallow G:U base pairs in the seed region, and a seed-match speed-up, which accelerates the program by a factor of 8. In addition, the program can now be used as a webservice for remote calls from user-implemented programs. We demonstrate RNAhybrid's flexibility with the prediction of a non-canonical target site for Caenorhabditis elegans miR-241 in the 3'-untranslated region of lin-39. RNAhybrid is available at http://bibiserv.techfak.uni-bielefeld.de/rnahybrid.
- Publication
Nucleic acids research, 2006, Vol 34, Issue Web Server issue, pW451
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkl243