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- Title
siVirus: web-based antiviral siRNA design software for highly divergent viral sequences.
- Authors
Naito, Yuki; Ui-Tei, Kumiko; Nishikawa, Toru; Takebe, Yutaka; Saigo, Kaoru
- Abstract
siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.
- Publication
Nucleic acids research, 2006, Vol 34, Issue Web Server issue, pW448
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkl214