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- Title
The structure and function of small nucleolar ribonucleoproteins.
- Authors
Reichow, Steve L; Hamma, Tomoko; Ferré-D'Amaré, Adrian R; Varani, Gabriele
- Abstract
Eukaryotes and archaea use two sets of specialized ribonucleoproteins (RNPs) to carry out sequence-specific methylation and pseudouridylation of RNA, the two most abundant types of modifications of cellular RNAs. In eukaryotes, these protein-RNA complexes localize to the nucleolus and are called small nucleolar RNPs (snoRNPs), while in archaea they are known as small RNPs (sRNP). The C/D class of sno(s)RNPs carries out ribose-2'-O-methylation, while the H/ACA class is responsible for pseudouridylation of their RNA targets. Here, we review the recent advances in the structure, assembly and function of the conserved C/D and H/ACA sno(s)RNPs. Structures of each of the core archaeal sRNP proteins have been determined and their assembly pathways delineated. Furthermore, the recent structure of an H/ACA complex has revealed the organization of a complete sRNP. Combined with current biochemical data, these structures offer insight into the highly homologous eukaryotic snoRNPs.
- Publication
Nucleic acids research, 2007, Vol 35, Issue 5, p1452
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkl1172