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- Title
cisRED: a database system for genome-scale computational discovery of regulatory elements.
- Authors
Robertson, G; Bilenky, M; Lin, K; He, A; Yuen, W; Dagpinar, M; Varhol, R; Teague, K; Griffith, O L; Zhang, X; Pan, Y; Hassel, M; Sleumer, M C; Pan, W; Pleasance, E D; Chuang, M; Hao, H; Li, Y Y; Robertson, N; Fjell, C; Li, B; Montgomery, S B; Astakhova, T; Zhou, J; Sander, J; Siddiqui, A S; Jones, S J M
- Abstract
We describe cisRED, a database for conserved regulatory elements that are identified and ranked by a genome-scale computational system (www.cisred.org). The database and high-throughput predictive pipeline are designed to address diverse target genomes in the context of rapidly evolving data resources and tools. Motifs are predicted in promoter regions using multiple discovery methods applied to sequence sets that include corresponding sequence regions from vertebrates. We estimate motif significance by applying discovery and post-processing methods to randomized sequence sets that are adaptively derived from target sequence sets, retain motifs with p-values below a threshold and identify groups of similar motifs and co-occurring motif patterns. The database offers information on atomic motifs, motif groups and patterns. It is web-accessible, and can be queried directly, downloaded or installed locally.
- Publication
Nucleic acids research, 2006, Vol 34, Issue Database issue, pD68
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkj075