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- Title
DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE.
- Authors
Malin, Stephen; Linderson, Ylva; Almqvist, Jenny; Ernberg, Ingemar; Tallone, Tiziano; Pettersson, Sven
- Abstract
POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in the conformational dependent inclusion or exclusion of the transcriptional coactivator OBF-1. In this paper, we demonstrate that Oct-1 and Oct-2 can function as transcriptional repressors by recruiting and physically interacting with members of the Grg/TLE family of corepressors. In accordance with a model of DNA induced cofactor assembly, and analogous to the recruitment of the OBF-1 coactivator, the different Grg/TLE members can discriminate between both Oct-1 and Oct-2, and the monomeric or dimeric nature of the POU/DNA complex.
- Publication
Nucleic acids research, 2005, Vol 33, Issue 14, p4618
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gki744