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- Title
A set of BAC clones spanning the human genome.
- Authors
Krzywinski, Martin; Bosdet, Ian; Smailus, Duane; Chiu, Readman; Mathewson, Carrie; Wye, Natasja; Barber, Sarah; Brown-John, Mabel; Chan, Susanna; Chand, Steve; Cloutier, Alison; Girn, Noreen; Lee, Darlene; Masson, Amara; Mayo, Michael; Olson, Teika; Pandoh, Pawan; Prabhu, Anna-Liisa; Schoenmakers, Eric; Tsai, Miranda; Albertson, Donna; Lam, Wan; Choy, Chik-On; Osoegawa, Kazutoyo; Zhao, Shaying; de Jong, Pieter J; Schein, Jacqueline; Jones, Steven; Marra, Marco A
- Abstract
Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32 855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease.
- Publication
Nucleic acids research, 2004, Vol 32, Issue 12, p3651
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkh700