We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
VISTA: computational tools for comparative genomics.
- Authors
Frazer, Kelly A; Pachter, Lior; Poliakov, Alexander; Rubin, Edward M; Dubchak, Inna
- Abstract
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here, we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-gsd.lbl.gov/vista/ was launched in the summer of 2000 and was designed to align long genomic sequences and visualize these alignments with associated functional annotations. Currently the VISTA site includes multiple comparative genomics tools and provides users with rich capabilities to browse pre-computed whole-genome alignments of large vertebrate genomes and other groups of organisms with VISTA Browser, to submit their own sequences of interest to several VISTA servers for various types of comparative analysis and to obtain detailed comparative analysis results for a set of cardiovascular genes. We illustrate capabilities of the VISTA site by the analysis of a 180 kb interval on human chromosome 5 that encodes for the kinesin family member 3A (KIF3A) protein.
- Publication
Nucleic acids research, 2004, Vol 32, Issue Web Server issue, pW273
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkh458