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- Title
DomIns: a web resource for domain insertions in known protein structures.
- Authors
Selvam, R Aroul; Sasidharan, Rajkumar
- Abstract
Proteins can be formed by single or multiple domains. The process of recombination at the molecular level has generated a wide variety of multi-domain proteins with specific domain organization to cater to the functional requirements of an organism. The functional and structural costs of inserting a domain into another means that multi-domain proteins are usually formed by covalently linking the N-terminus of one domain to the C-terminus of the preceding domain. While this is true in a large proportion of multi-domain proteins, we find a significant fraction of proteins that are the result of domain insertion. The inserted domain breaks the sequence contiguity of the domain into which it is inserted leading to a novel domain organization. This web resource aims to document domain insertions in known protein structures that are classified in the SCOP database. The web server can be accessed from http://stash.mrc-lmb.cam. ac.uk/DomIns/.
- Publication
Nucleic acids research, 2004, Vol 32, Issue Database issue, pD193
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkh047