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- Title
The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms.
- Authors
McGuffin, Liam J; Street, Stefano A; Bryson, Kevin; Sørensen, Søren-Aksel; Jones, David T
- Abstract
Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The Gen THREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.
- Publication
Nucleic acids research, 2004, Vol 32, Issue Database issue, pD196
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkh043