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- Title
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.
- Authors
Uil, Taco G; Haisma, Hidde J; Rots, Marianne G
- Abstract
Designer molecules that can specifically target pre-determined DNA sequences provide a means to modulate endogenous gene function. Different classes of sequence-specific DNA-binding agents have been developed, including triplex-forming molecules, synthetic polyamides and designer zinc finger proteins. These different types of designer molecules with their different principles of engineered sequence specificity are reviewed in this paper. Furthermore, we explore and discuss the potential of these molecules as therapeutic modulators of endogenous gene function, focusing on modulation by stable gene modification and by regulation of gene transcription.
- Publication
Nucleic acids research, 2003, Vol 31, Issue 21, p6064
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkg815