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- Title
DNA sequence representation without degeneracy.
- Authors
Yau, Stephen S-T; Wang, Jiasong; Niknejad, Amir; Lu, Chaoxiao; Jin, Ning; Ho, Yee-Kin
- Abstract
Graphical representation of DNA sequence provides a simple way of viewing, sorting and comparing various gene structures. A new two-dimensional graphical representation method using a two- quadrant Cartesian coordinates system has been derived for mathematical denotation of DNA sequence. The two-dimensional graphic representation resolves sequences' degeneracy and is mathematically proven to eliminate circuit formation. Given x-projection and y-projection of any point on the graphical representation, the number of A, G, C and T from the beginning of the sequence to that point could be found. Compared with previous methods, this graphical representation is more in-line with the conventional recognition of linear sequences by molecular biologists, and also provides a metaphor in two dimensions for local and global DNA sequence comparison.
- Publication
Nucleic acids research, 2003, Vol 31, Issue 12, p3078
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkg432