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- Title
Analysis of repeatability in spotted cDNA microarrays.
- Authors
Jenssen, Tor-Kristian; Langaas, Mette; Kuo, Winston P; Smith-Sørensen, Birgitte; Myklebost, Ola; Hovig, Eivind
- Abstract
We report a strategy for analysis of data quality in cDNA microarrays based on the repeatability of repeatedly spotted clones. We describe how repeatability can be used to control data quality by developing adaptive filtering criteria for microarray data containing clones spotted in multiple spots. We have applied the method on five publicly available cDNA microarray data sets and one previously unpublished data set from our own laboratory. The results demonstrate the feasibility of the approach as a foundation for data filtering, and indicate a high degree of variation in data quality, both across the data sets and between arrays within data sets.
- Publication
Nucleic acids research, 2002, Vol 30, Issue 14, p3235
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/gkf441