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- Title
Wild-derived inbred mouse strains have short telomeres.
- Authors
Hemann, M T; Greider, C W
- Abstract
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
- Publication
Nucleic acids research, 2000, Vol 28, Issue 22, p4474
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/28.22.4474