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- Title
STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.
- Authors
Snel, B; Lehmann, G; Bork, P; Huynen, M A
- Abstract
The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.
- Publication
Nucleic acids research, 2000, Vol 28, Issue 18, p3442
- ISSN
1362-4962
- Publication type
Journal Article
- DOI
10.1093/nar/28.18.3442