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- Title
tRNA recognition and evolution of determinants in seryl-tRNA synthesis.
- Authors
Lenhard, B; Orellana, O; Ibba, M; Weygand-Durasević, I
- Abstract
We have analyzed the evolution of recognition of tRNAsSerby seryl-tRNA synthetases, and compared it to other type 2 tRNAs, which contain a long extra arm. In Eubacteria and chloroplasts this type of tRNA is restricted to three families: tRNALeu, tRNASer and tRNATyr. tRNALeuand tRNASer also carry a long extra arm in Archaea, Eukarya and all organelles with the exception of animal mitochondria. In contrast, the long extra arm of tRNATyr is far less conserved: it was drastically shortened after the separation of Archaea and Eukarya from Eubacteria, and it is also truncated in animal mitochondria. The high degree of phylo-genetic divergence in the length of tRNA variable arms, which are recognized by both class I and class II aminoacyl-tRNA synthetases, makes type 2 tRNA recognition an ideal system with which to study how tRNA discrimination may have evolved in tandem with the evolution of other components of the translation machinery.
- Publication
Nucleic acids research, 1999, Vol 27, Issue 3, p721
- ISSN
0305-1048
- Publication type
Journal Article
- DOI
10.1093/nar/27.3.721