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- Title
Fluorescent in-situ hybridization and sequence-tagged sites for delineation of an X:Y translocation in a patient with secondary amenorrhoea.
- Authors
Delon, B; Lallaoui, H; Abel-Lablanche, C; Geneix, A; Bellec, V; Benkhalifa, M
- Abstract
We describe a phenotypically normal female with secondary amenorrhoea due to a translocation of genetic material involving the long arm of chromosome X (Xq28) and the long arm of chromosome Y (Yq11). We used fluorescent in situ hybridization to localize the breakpoint on the Xq. The Y chromosome breakpoint was identified using polymerase chain reaction (PCR) detection of sequence-tagged sites (STS) specific for interval 5 at Yq11.21. The relationship between this X:Y translocation and premature ovarian failure is discussed.
- Publication
Molecular human reproduction, 1997, Vol 3, Issue 5, p439
- ISSN
1360-9947
- Publication type
Journal Article
- DOI
10.1093/molehr/3.5.439