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- Title
Evolution of 7SK RNA and its protein partners in metazoa.
- Authors
Marz, Manja; Donath, Alexander; Verstraete, Nina; Nguyen, Van Trung; Stadler, Peter F; Bensaude, Olivier
- Abstract
7SK RNA is a key player in the regulation of polymerase II transcription. 7SK RNA was considered as a highly conserved vertebrate innovation. The discovery of poorly conserved homologs in several insects and lophotrochozoans, however, implies a much earlier evolutionary origin. The mechanism of 7SK function requires interaction with the proteins HEXIM and La-related protein 7. Here, we present a comprehensive computational analysis of these two proteins in metazoa, and we extend the collection of 7SK RNAs by several additional candidates. In particular, we describe 7SK homologs in Caenorhabditis species. Furthermore, we derive an improved secondary structure model of 7SK RNA, which shows that the structure is quite well-conserved across animal phyla despite the extreme divergence at sequence level.
- Publication
Molecular biology and evolution, 2009, Vol 26, Issue 12, p2821
- ISSN
1537-1719
- Publication type
Journal Article
- DOI
10.1093/molbev/msp198