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- Title
Adjusting for selection on synonymous sites in estimates of evolutionary distance.
- Authors
Hirsh, Aaron E; Fraser, Hunter B; Wall, Dennis P
- Abstract
Evolution at silent sites is often used to estimate the pace of selectively neutral processes or to infer differences in divergence times of genes. However, silent sites are subject to selection in favor of preferred codons, and the strength of such selection varies dramatically across genes. Here, we use the relationship between codon bias and synonymous divergence observed in four species of the genus Saccharomyces to provide a simple correction for selection on silent sites.
- Publication
Molecular biology and evolution, 2005, Vol 22, Issue 1, p174
- ISSN
0737-4038
- Publication type
Journal Article
- DOI
10.1093/molbev/msh265