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- Title
Neutral mutations and neutral substitutions in bacterial genomes.
- Authors
Ochman, Howard
- Abstract
Molecular evolutionary biologists usually assess the underlying spectrum of mutations within a bacterial genome by examining substitutions that occur at sites believed to be under no selective constraints. Alternatively, bacterial mutation rates can also be estimated in a variety of experimental systems. The two classes of changes occurring in DNA sequences-i.e., mutations and neutral substitutions-are, in theory, identical; however, the rates and patterns of mutations in bacteria, as inferred from sequence comparisons, often differ significantly from those derived experimentally. These differences have resulted in conflicting interpretations of the nonselective forces that affect mutation rates.
- Publication
Molecular biology and evolution, 2003, Vol 20, Issue 12, p2091
- ISSN
0737-4038
- Publication type
Journal Article
- DOI
10.1093/molbev/msg229