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- Title
Role of the tripartite motif protein 27 in cancer development.
- Authors
Zoumpoulidou, Georgia; Broceño, Cristina; Li, He; Bird, Demelza; Thomas, George; Mittnacht, Sibylle
- Abstract
The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here, we investigated the role of TRIM27 expression in cancer development.
- Publication
Journal of the National Cancer Institute, 2012, Vol 104, Issue 12, p941
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djs224