We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.
- Authors
Roberts, Patrick J; Bisi, John E; Strum, Jay C; Combest, Austin J; Darr, David B; Usary, Jerry E; Zamboni, William C; Wong, Kwok-Kin; Perou, Charles M; Sharpless, Norman E
- Abstract
Cyclin-dependent kinases (CDKs) regulate cell proliferation and coordinate the cell cycle checkpoint response to DNA damage. Although inhibitors with varying selectivity to specific CDK family members have been developed, selective CDK4/6 inhibitors have emerged as the most attractive antineoplastic agents because of the importance of CDK4/6 activity in regulating cell proliferation and the toxic effects associated with inhibition of other CDKs (eg, CDK1 and CDK2).
- Publication
Journal of the National Cancer Institute, 2012, Vol 104, Issue 6, p476
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djs002