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- Title
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
- Authors
Ihle, Nathan T; Byers, Lauren A; Kim, Edward S; Saintigny, Pierre; Lee, J Jack; Blumenschein, George R; Tsao, Anne; Liu, Suyu; Larsen, Jill E; Wang, Jing; Diao, Lixia; Coombes, Kevin R; Chen, Lu; Zhang, Shuxing; Abdelmelek, Mena F; Tang, Ximing; Papadimitrakopoulou, Vassiliki; Minna, John D; Lippman, Scott M; Hong, Waun K; Herbst, Roy S; Wistuba, Ignacio I; Heymach, John V; Powis, Garth
- Abstract
Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell growth and resistance to therapy. Most mutations occur at codons 12 and 13. In colorectal cancer, the presence of any mutant KRas amino acid substitution is a negative predictor of patient response to targeted therapy. However, in non-small cell lung cancer (NSCLC), the evidence that KRAS mutation is a predictive factor is conflicting.
- Publication
Journal of the National Cancer Institute, 2012, Vol 104, Issue 3, p228
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djr523