We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Differentiation therapy: targeting human renal cancer stem cells with interleukin 15.
- Authors
Azzi, Sandy; Bruno, Stefania; Giron-Michel, Julien; Clay, Denis; Devocelle, Aurore; Croce, Michela; Ferrini, Silvano; Chouaib, Salem; Vazquez, Aimé; Charpentier, Bernard; Camussi, Giovanni; Azzarone, Bruno; Eid, Pierre
- Abstract
Many renal cancer patients experience disease recurrence after immunotherapy or combined treatments due to persistence of cancer stem cells (CSCs). The identification of reliable inducers of CSC differentiation may facilitate the development of efficient strategies for eliminating CSCs. We investigated whether interleukin 15 (IL-15), a regulator of kidney homeostasis, induces the differentiation of CD105-positive (CD105(+)) CSCs from human renal cancers.
- Publication
Journal of the National Cancer Institute, 2011, Vol 103, Issue 24, p1884
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djr451