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- Title
Opportunities and challenges in the development of experimental drug combinations for cancer.
- Authors
W Humphrey R; M Brockway-Lunardi L; T Bonk D; Dohoney KM; Doroshow JH; Meech SJ; Ratain MJ; Topalian SL; M Pardoll D; Humphrey, Rachel W; Brockway-Lunardi, Laura M; Bonk, David T; Dohoney, Kathleen M; Doroshow, James H; Meech, Sandra J; Ratain, Mark J; Topalian, Suzanne L; Pardoll, Drew M
- Abstract
It is becoming increasingly evident that cancers are dependent on a number of altered molecular pathways and can develop diverse mechanisms of resistance to therapy with single agents. Therefore, combination regimens may provide the best hope for effective therapies with durable effects. Despite preclinical data to support this notion, there are many challenges to the development of targeted combinations including scientific, economic, legal, and regulatory barriers. A discussion of these challenges and identification of models and best practices are presented with intent of aiding the research community in addressing real and perceived barriers to the development of combination therapies for cancer.
- Publication
JNCI: Journal of the National Cancer Institute, 2011, Vol 103, Issue 16, p1222
- ISSN
0027-8874
- Publication type
Academic Journal
- DOI
10.1093/jnci/djr246