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- Title
Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement.
- Authors
Mackay, Alan; Weigelt, Britta; Grigoriadis, Anita; Kreike, Bas; Natrajan, Rachael; A'Hern, Roger; Tan, David S P; Dowsett, Mitch; Ashworth, Alan; Reis-Filho, Jorge S
- Abstract
Breast cancers can be classified by hierarchical clustering using an "intrinsic" gene list into one of at least five molecular subtypes: basal-like, HER2, luminal A, luminal B, and normal breast-like. Five different intrinsic gene lists composed of varying numbers of genes have been used for molecular subtype identification and classification of breast cancers. The aim of this study was to determine the objectivity and interobserver reproducibility of the assignment of molecular subtype classes by hierarchical cluster analysis.
- Publication
Journal of the National Cancer Institute, 2011, Vol 103, Issue 8, p662
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djr071