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- Title
Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer.
- Authors
Gillessen, Silke; Templeton, Arnoud; Marra, Giancarlo; Kuo, Yong-Fang; Valtorta, Emanuele; Shahinian, Vahakn B
- Abstract
Androgen deprivation with gonadotropin-releasing hormone (GnRH) agonists or orchiectomy is a common but controversial treatment for prostate cancer. Uncertainties remain about its use, particularly with increasing recognition of serious side effects. In animal studies, androgens protect against colonic carcinogenesis, suggesting that androgen deprivation may increase the risk of colorectal cancer.
- Publication
Journal of the National Cancer Institute, 2010, Vol 102, Issue 23, p1760
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djq419