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- Title
GLI2-mediated melanoma invasion and metastasis.
- Authors
Alexaki, Vasileia-Ismini; Javelaud, Delphine; Van Kempen, Leon C L; Mohammad, Khalid S; Dennler, Sylviane; Luciani, Flavie; Hoek, Keith S; Juàrez, Patricia; Goydos, James S; Fournier, Pierrick J; Sibon, Claire; Bertolotto, Corine; Verrecchia, Franck; Saule, Simon; Delmas, Veronique; Ballotti, Robert; Larue, Lionel; Saiag, Philippe; Guise, Theresa A; Mauviel, Alain
- Abstract
The transforming growth factor-beta (TGF-beta) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in melanoma and is a marker of poor prognosis. Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional target of TGF-beta signaling.
- Publication
Journal of the National Cancer Institute, 2010, Vol 102, Issue 15, p1148
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djq257