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- Title
Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.
- Authors
Van Maerken, Tom; Ferdinande, Liesbeth; Taildeman, Jasmien; Lambertz, Irina; Yigit, Nurten; Vercruysse, Liesbeth; Rihani, Ali; Michaelis, Martin; Cinatl, Jindrich, Jr; Cuvelier, Claude A; Marine, Jean-Christophe; De Paepe, Anne; Bracke, Marc; Speleman, Frank; Vandesompele, Jo
- Abstract
Restoring p53 function by antagonizing its interaction with the negative regulator MDM2 is an appealing nongenotoxic approach to treating tumors with wild-type p53. Mutational inactivation of p53 is rare in neuroblastoma tumors at diagnosis and occurs in only a subset of multidrug-resistant neuroblastomas.
- Publication
Journal of the National Cancer Institute, 2009, Vol 101, Issue 22, p1562
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djp355