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- Title
Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.
- Authors
Gunter, Marc J; Hoover, Donald R; Yu, Herbert; Wassertheil-Smoller, Sylvia; Rohan, Thomas E; Manson, JoAnn E; Li, Jixin; Ho, Gloria Y F; Xue, Xiaonan; Anderson, Garnet L; Kaplan, Robert C; Harris, Tiffany G; Howard, Barbara V; Wylie-Rosett, Judith; Burk, Robert D; Strickler, Howard D
- Abstract
The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level.
- Publication
Journal of the National Cancer Institute, 2009, Vol 101, Issue 1, p48
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djn415