We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer.
- Authors
Pengyuan Liu; Vikis, Hans G.; Daolong Wang; Yan Lu; Yian Wang; Schwartz, Ann G.; Pinney, Susan M.; Ping Yang; de Andrade, Mariza; Petersen, Gloria M.; Wiest, Jonathan S.; Fain, Pamela R.; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Juwon Lee; Kupert, Elena; Seminara, Daniela
- Abstract
Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than five- fold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [Cl] = 2.21 to 23.37) or rs1051730 (OR = 5.67, Cl = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
- Publication
JNCI: Journal of the National Cancer Institute, 2008, Vol 100, Issue 18, p1326
- ISSN
0027-8874
- Publication type
Academic Journal
- DOI
10.1093/jnci/djn268