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- Title
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
- Authors
Setlur, Sunita R; Mertz, Kirsten D; Hoshida, Yujin; Demichelis, Francesca; Lupien, Mathieu; Perner, Sven; Sboner, Andrea; Pawitan, Yudi; Andrén, Ove; Johnson, Laura A; Tang, Jeff; Adami, Hans-Olov; Calza, Stefano; Chinnaiyan, Arul M; Rhodes, Daniel; Tomlins, Scott; Fall, Katja; Mucci, Lorelei A; Kantoff, Philip W; Stampfer, Meir J; Andersson, Swen-Olof; Varenhorst, Eberhard; Johansson, Jan-Erik; Brown, Myles; Golub, Todd R; Rubin, Mark A
- Abstract
The majority of prostate cancers harbor gene fusions of the 5'-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation-specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate cancer defined by this fusion.
- Publication
Journal of the National Cancer Institute, 2008, Vol 100, Issue 11, p815
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djn150