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- Title
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy.
- Authors
Kurozumi, Kazuhiko; Hardcastle, Jayson; Thakur, Roopa; Yang, Ming; Christoforidis, Gregory; Fulci, Giulia; Hochberg, Fred H; Weissleder, Ralph; Carson, William; Chiocca, E Antonio; Kaur, Balveen
- Abstract
The tumor microenvironment is being increasingly recognized as an important determinant of tumor progression as well as of therapeutic response. We investigated oncolytic virus (OV) therapy-induced changes in tumor blood vessels and the impact of modulating tumor vasculature on the efficacy of oncolytic virus therapy.
- Publication
Journal of the National Cancer Institute, 2007, Vol 99, Issue 23, p1768
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djm229