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- Title
Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.
- Authors
Hosey, Alison M; Gorski, Julia J; Murray, Margaret M; Quinn, Jennifer E; Chung, Wen Y; Stewart, Gail E; James, Colin R; Farragher, Susan M; Mulligan, Jude M; Scott, Alistair N; Dervan, Peter A; Johnston, Patrick G; Couch, Fergus J; Daly, Peter A; Kay, Elaine; McCann, Amanda; Mullan, Paul B; Harkin, D Paul
- Abstract
BRCA1-mutant breast tumors are typically estrogen receptor alpha (ER alpha) negative, whereas most sporadic tumors express wild-type BRCA1 and are ER alpha positive. We examined a possible mechanism for the observed ER alpha-negative phenotype of BRCA1-mutant tumors.
- Publication
Journal of the National Cancer Institute, 2007, Vol 99, Issue 22, p1683
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djm207