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- Title
Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study.
- Authors
Taguchi, Fumiko; Solomon, Benjamin; Gregorc, Vanesa; Roder, Heinrich; Gray, Robert; Kasahara, Kazuo; Nishio, Makoto; Brahmer, Julie; Spreafico, Anna; Ludovini, Vienna; Massion, Pierre P; Dziadziuszko, Rafal; Schiller, Joan; Grigorieva, Julia; Tsypin, Maxim; Hunsucker, Stephen W; Caprioli, Richard; Duncan, Mark W; Hirsch, Fred R; Bunn, Paul A, Jr; Carbone, David P
- Abstract
Some but not all patients with non-small-cell lung cancer (NSCLC) respond to treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We developed and tested the ability of a predictive algorithm based on matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) analysis of pretreatment serum to identify patients who are likely to benefit from treatment with EGFR TKIs.
- Publication
Journal of the National Cancer Institute, 2007, Vol 99, Issue 11, p838
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djk195