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- Title
The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions.
- Authors
Hameetman, Liesbeth; Szuhai, Karoly; Yavas, Ayse; Knijnenburg, Jeroen; van Duin, Mark; van Dekken, Herman; Taminiau, Antonie H M; Cleton-Jansen, Anne-Marie; Bovée, Judith V M G; Hogendoorn, Pancras C W
- Abstract
Multiple osteochondromas is a hereditary syndrome that is characterized by the formation of cartilage-capped bony neoplasms (osteochondromas), for which exostosis (multiple)-1 (EXT1) has been identified as a causative gene. However, 85% of all osteochondromas present as solitary (nonhereditary) lesions in which somatic mutations in EXT1 are extremely rare, but loss of heterozygosity and clonal rearrangement of 8q24 (the chromosomal locus of EXT1) are common. We examined whether EXT1 might act as a classical tumor suppressor gene for nonhereditary osteochondromas.
- Publication
Journal of the National Cancer Institute, 2007, Vol 99, Issue 5, p396
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djk067