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- Title
Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification.
- Authors
Asgharzadeh, Shahab; Pique-Regi, Roger; Sposto, Richard; Wang, Hong; Yang, Yujun; Shimada, Hiroyuki; Matthay, Katherine; Buckley, Jonathan; Ortega, Antonio; Seeger, Robert C
- Abstract
The aggressiveness of metastatic neuroblastomas that lack MYCN gene amplification varies with age--they are least aggressive when diagnosed in patients younger than 12 months and most aggressive when diagnosed in patients older than 24 months. However, age at diagnosis is not always associated with patient survival. We examined whether molecular classification of metastatic neuroblastomas without MYCN gene amplification at diagnosis using gene expression profiling could improve the prediction of risk of disease progression.
- Publication
Journal of the National Cancer Institute, 2006, Vol 98, Issue 17, p1193
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djj330