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- Title
Extended lung cancer incidence follow-up in the Mayo Lung Project and overdiagnosis.
- Authors
Marcus, Pamela M; Bergstralh, Erik J; Zweig, Mark H; Harris, Ann; Offord, Kenneth P; Fontana, Robert S
- Abstract
A troubling aspect of cancer screening is the potential for overdiagnosis, i.e., detection of disease that, in the absence of screening, would never have been diagnosed. Overdiagnosis is of particular concern in lung cancer screening because newer screening modalities can identify small nodules of unknown clinical significance. Previously published analyses of data from the Mayo Lung Project, a large randomized controlled trial conducted among 9211 male cigarette smokers in the 1970s and early 1980s indicated that overdiagnosis might exist in lung cancer screening. At the end of follow-up (July 1, 1983), no difference in lung cancer mortality was observed, but an excess of 46 cases in the intervention arm suggested overdiagnosis. Because that excess could instead have resulted from short follow-up time, we investigated this possibility by conducting long-term lung cancer incidence follow-up.
- Publication
Journal of the National Cancer Institute, 2006, Vol 98, Issue 11, p748
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djj207