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- Title
Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.
- Authors
Tada, Yasuhiro; Brena, Romulo Martin; Hackanson, Björn; Morrison, Carl; Otterson, Gregory A; Plass, Christoph
- Abstract
Loss of tumor suppressor CCAAT/enhancer-binding protein-alpha (C/EBPalpha) expression is seen in several human malignancies, including acute myelogenous leukemia and lung cancer. We hypothesized that DNA methylation and histone acetylation of the C/EBPalpha promoter may modulate C/EBPalpha expression in lung cancer.
- Publication
Journal of the National Cancer Institute, 2006, Vol 98, Issue 6, p396
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djj093