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Title
BAY 43-9006 inhibition of oncogenic RET mutants.
Authors
Carlomagno, Francesca; Anaganti, Suresh; Guida, Teresa; Salvatore, Giuliana; Troncone, Giancarlo; Wilhelm, Scott M; Santoro, Massimo
Abstract
Medullary and papillary thyroid carcinomas are often associated with oncogenic activation of the RET tyrosine kinase. We evaluated whether the biaryl urea BAY 43-9006, which is known to inhibit several other tyrosine kinases, blocks RET kinase function and oncogenic activity.
Publication
Journal of the National Cancer Institute, 2006, Vol 98, Issue 5, p326