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- Title
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.
- Authors
Alexandre, Jérôme; Nicco, Carole; Chéreau, Christiane; Laurent, Alexis; Weill, Bernard; Goldwasser, François; Batteux, Frédéric
- Abstract
Anticancer drugs act by increasing intracellular hydrogen peroxide levels. Mangafodipir, a superoxide dismutase (SOD) mimic with catalase and glutathione reductase activities, protects normal cells from apoptosis induced by H2O2. We investigated its and other oxidative stress modulators' effects on anticancer drug activity in vitro and in vivo.
- Publication
Journal of the National Cancer Institute, 2006, Vol 98, Issue 4, p236
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djj049