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- Title
Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.
- Authors
Dilda, Pierre J; Don, Anthony S; Tanabe, Kara M; Higgins, Vincent J; Allen, John D; Dawes, Ian W; Hogg, Philip J
- Abstract
The synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is an angiogenesis inhibitor that targets the mitochondria of actively dividing but not quiescent endothelial cells, arresting their proliferation and causing apoptosis. Normal endothelial cells are much more sensitive to GSAO than tumor cells. To elucidate the mechanism of tumor cell resistance, we identified yeast genes that are necessary for resistance to GSAO.
- Publication
Journal of the National Cancer Institute, 2005, Vol 97, Issue 20, p1539
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/dji316