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- Title
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
- Authors
Shigematsu, Hisayuki; Lin, Li; Takahashi, Takao; Nomura, Masaharu; Suzuki, Makoto; Wistuba, Ignacio I; Fong, Kwun M; Lee, Huei; Toyooka, Shinichi; Shimizu, Nobuyoshi; Fujisawa, Takehiko; Feng, Ziding; Roth, Jack A; Herz, Joachim; Minna, John D; Gazdar, Adi F
- Abstract
Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear.
- Publication
Journal of the National Cancer Institute, 2005, Vol 97, Issue 5, p339
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/dji055