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- Title
The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements.
- Authors
Goodman, Gary E; Thornquist, Mark D; Balmes, John; Cullen, Mark R; Meyskens, Frank L, Jr; Omenn, Gilbert S; Valanis, Barbara; Williams, James H, Jr
- Abstract
The Beta-Carotene and Retinol Efficacy Trial (CARET) tested the effect of daily beta-carotene (30 mg) and retinyl palmitate (25,000 IU) on the incidence of lung cancer, other cancers, and death in 18,314 participants who were at high risk for lung cancer because of a history of smoking or asbestos exposure. CARET was stopped ahead of schedule in January 1996 because participants who were randomly assigned to receive the active intervention were found to have a 28% increase in incidence of lung cancer, a 17% increase in incidence of death and a higher rate of cardiovascular disease mortality compared with participants in the placebo group.
- Publication
Journal of the National Cancer Institute, 2004, Vol 96, Issue 23, p1743
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djh320