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- Title
Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies.
- Authors
Brunstein, Flavia; Hoving, Saske; Seynhaeve, Ann L B; van Tiel, Sandra T; Guetens, Gunther; de Bruijn, Ernst A; Eggermont, Alexander M M; ten Hagen, Timo L M
- Abstract
We have previously shown how tumor response of isolated limb perfusion (ILP) with melphalan was improved when tumor necrosis factor alpha (TNF-alpha) was added. Taking into account that other vasoactive drugs could also improve tumor response to ILP, we evaluated histamine (Hi) as an alternative to TNF-alpha.
- Publication
Journal of the National Cancer Institute, 2004, Vol 96, Issue 21, p1603
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djh300