We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect on tumor cells of blocking survival response to glucose deprivation.
- Authors
Park, Hae-Ryong; Tomida, Akihiro; Sato, Shigeo; Tsukumo, Yoshinori; Yun, Jisoo; Yamori, Takao; Hayakawa, Yoichi; Tsuruo, Takashi; Shin-ya, Kazuo
- Abstract
Glucose deprivation, a feature of poorly vascularized solid tumors, activates the unfolded protein response (UPR), a stress-signaling pathway, in tumor cells. We recently isolated a novel macrocyclic compound, versipelostatin (VST), that inhibits transcription from the promoter of GRP78, a gene that is activated as part of the UPR. We examined the effect of VST on the UPR induced by glucose deprivation or other stressors and on tumor growth in vivo.
- Publication
Journal of the National Cancer Institute, 2004, Vol 96, Issue 17, p1300
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djh243